Located on a quiet Harlem side-street in a gorgeous brownstone, 102 Brownstone's six rooms comprise a homey Uptown nest.

The Ameritania, a three-star hotel ideally located at 54th and Broadway, offers reasonably priced rooms with a boutique style.

The 79-room Broadway @ Times Square Hotel eschews the bright lights and and blaring marquees of nearby Times Square in favor of more traditional décor.

The Chelsea Lodge has been run as a guesthouse since 1999, when it was radically re-engineered from a decrepit boarding house into a cozy inn.

The Chelsea Pines Inn is a cheerful and popular spot offering friendly service, a convenient location and touches of old-Hollywood glamour.

The Chelsea Star is an interesting beast, with hostel dormitories, cheap artist-shaped rooms with shared-facilities, and deluxe rooms with massive amounts of space.

The ethos is communal, funky, and friendly. There are bikes, umbrellas, and museum passes on offer, all free for guests.

Perched on the edge of Hell's Kitchen, at 47th Street and 8th Avenue, the Econo Lodge Times Square certainly offers convenience.

The 150-room Gershwin is a well-executed hotel thriving on the crazy energy of 1970s New York.

The lobby décor at the 300-room Hampton Inn Times Square is surprisingly contemporary for a midrange chain hotel.

Stylish, cozy boutique hotels do exist in bustling, chain-hotel-dominated Midtown. The three-star Hotel 414 is one of them—and it's affordable, to boot.